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341088

Sigma-Aldrich

1,9-Dimethyl-Methylene Blue zinc chloride double salt

Dye content 80 %

Synonyme(s) :

DMMB, Taylor’s Blue

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About This Item

Formule empirique (notation de Hill):
C18H22ClN3S · 0.5ZnCl2
Numéro CAS:
931418-92-7
Poids moléculaire :
416.05
Numéro MDL:
MFCD19686959
Code UNSPSC :
12171500
ID de substance PubChem :
24860900
Nomenclature NACRES :
NA.47

Forme

powder

Niveau de qualité

200

Composition

Dye content, 80%

Technique(s)

titration: suitable

Impuretés

<20% water

Pf

250 °C (dec.) (lit.)

λmax

649 nm

ε (coefficient d'extinction)

≥10000 at 243-249 nm in H2O
≥18000 at 285-291 nm in H2O
≥25000 at 594-600 nm in H2O
≥35000 at 646-652 nm in H2O

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

[Cl-].[Cl-].Cl[Zn]Cl.CN(C)c1cc(C)c2N=C3C(C)=C\C(C=C3Sc2c1)=[N+](/C)C.CN(C)c4cc(C)c5N=C6C(C)=C\C(C=C6Sc5c4)=[N+](/C)C

InChI

1S/2C18H22N3S.4ClH.Zn/c2*1-11-7-13(20(3)4)9-15-17(11)19-18-12(2)8-14(21(5)6)10-16(18)22-15;;;;;/h2*7-10H,1-6H3;4*1H;/q2*+1;;;;;+2/p-4

Clé InChI

MKLBAKXCEQNMBC-UHFFFAOYSA-J

Application

1,9-Dimethyl-Methylene Blue zinc chloride double salt has been used for the quantification of sulfated glycosaminoglycans.
DMMB is a cationic dye that specifically binds to sulfated glycosaminoglycans (sGAG) with an absorbance at ~525 nm. It has been used to quantitate glycosaminoglyans such as chondroitin sulfate, keratin sulfate, and heparan sulfate and sGAG chains in proteoglycans. One limitation to this method The sGAG-DMMB complex is unstable in solution and may precipitate. Precipitation of the complex was shown to improve stability.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Conseils de prudence

P305 + P351 + P338

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
MKCM5250
MKCH6422
MKCF2084
MKCF2085
MKCF2192

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Consulter la Bibliothèque de documents

Yi He et al.
FEBS open bio, 9(6), 1144-1152 (2019-05-01)
Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that
P Behrendt et al.
Osteoarthritis and cartilage, 24(11), 1981-1988 (2016-10-21)
The aim of this study was to examine whether anti-inflammatory interleukin-10 (IL-10) exerts chondroprotective effects in an in vitro model of a single mechanical injury of mature articular cartilage. Articular cartilage was harvested from the femoro-patellar groove of adult cows (Bos
Makwese Maepa et al.
Tissue engineering. Part A, 25(15-16), 1137-1145 (2018-12-05)
Eucomis autumnalis is one plant that is used by various traditional healers to alleviate the signs and symptoms associated with osteoarthritis. Although the exact mechanisms remain unknown, we hypothesized that this plant can induce chondrogenesis. In this work, we explored
Anita Krouwels et al.
Spine, 43(5), 307-315 (2015-04-10)
An in vitro study using human degenerated nucleus pulposus cells. To determine the effect of osmolality and different osmolytes on the regeneration by human nucleus pulposus cells through gene expression and extracellular matrix production. Intervertebral disc (IVD) degeneration is a
Ana C Zarpelon et al.
Inflammation, 40(6), 2020-2032 (2017-08-07)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway
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