17929

O-Methyl-O′-succinylpolyethylene glycol 5′000

• Synonyme(s) : Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate
• Formule linéaire : CH₃O(CH₂CH₂O)_nCOCH₂CH₂COOH
• Numéro CAS: 31961-02-1
• Numéro MDL: MFCD00284260
• Code UNSPSC : 51171641
• Nomenclature NACRES : NA.26

Propriétés

• Forme: powder
• Poids mol.: M_r ~5100
• Pf: 56-60 °C
• Extrémité Ω: carboxylic acid
• Extrémité α: methoxy
• Température de stockage: −20°C

Description

Application

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Actions biochimiques/physiologiques

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves