ABT406

Anti-LRRFIP1 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Leucine-rich repeat flightless-interacting protein 1, LRR FLII-interacting protein 1, GC-binding factor 2, TAR RNA-interacting protein
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Technique(s): western blot: suitable
• Numéro d'accès UniProt: Q32MZ4
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... LRRFIP1(9208)

Description

Description générale

Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1), also known as GC-binding factor 2 or TAR RNA-interacting protein, and encoded by the gene name LRRFIP1 or GCF2 or TRIP, is a transcriptional repressor that mainly plays a cytoskeletal role. LRRFIP1 is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a β-catenindependent pathway.

Immunogène

KLH-conjugated synthetic peptide corresponding to human LRRFIP1.

Application

Anti-LRRFIP1 Antibody detects level of LRRFIP1 & has been published & validated for use in LRRFIP1.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

Qualité

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected LRRFIP1 in human colon tissue lysate.

Description de la cible

~85 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 4 isoforms produced by alternative splicing ranging between ~73 kDa and ~89 kDa

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable