8.52418

Fmoc-Asp(OBno)-OH

Novabiochem^®

• Synonyme(s) : Fmoc-Asp(OBno)-OH
• Formule empirique (notation de Hill): C₃₂H₄₃NO₆
• Poids moléculaire : 537.69
• Code UNSPSC : 12352209

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Forme: powder
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: carboxylic acid
• Température de stockage: −20°C (−15°C to −25°C)

Description

Description générale

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS, including those containing the Asp-Gly sequence. The bulky OBno protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu and OMpe group.^,

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aspartimide Formation in Fmoc SPPS

Literature references:
^[1] R. Behrendt, et al. (2015) J. Pept. Sci., 21, 680.
^[2] R. Behrendt, et al. (2016) J. Pept. Sci., 22, 92.

Application

Recently, Fmoc-Asp(OBno)-OH has been used in the synthesis of the mini-protein Omomyc, which has been shown to repress MYC-dependent gene transcription.,

Remarque sur l'analyse

Color (visual): white to beige
Appearance of substance (visual): powder, chunks or crystals
Identity (IR): passes test
Purity (TLC (018A)): ≥ 95 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable