8.52101

Fmoc-Arg(Boc)₂-OH

Novabiochem^®

• Synonyme(s) : Fmoc-Arg(Boc)₂-OH, N-α-Fmoc-N-ω,N-ωÆ-bis-t-butoxycarbonyl-L-arginine
• Formule empirique (notation de Hill): C₃₁H₄₀N₄O₈
• Numéro CAS: 143824-77-5
• Poids moléculaire : 596.67
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Pureté: ≥90.0% (acidimetric); ≥91.0% (HPLC); ≥95% (TLC)
• Forme: powder
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: Boc; Fmoc
• Température de stockage: 15-25°C
• InChI: 1S/C31H40N4O8/c1-30(2,3)42-28(39)34-26(35-29(40)43-31(4,5)6)32-17-11-16-24(25(36)37)33-27(38)41-18-23-21-14-9-7-12-19(21)20-13-8-10-15-22(20)23/h7-10,12-15,23-24H,11,16-18H2,1-6H3,(H,33,38)(H,36,37)(H2,32,34,35,39,40)/t24-/m0/s1
• Clé InChI: WPAALELGEWGQEG-DEOSSOPVSA-N

Description

Description générale

An excellent derivative for Fmoc SPPS of Arg-containing peptides ^[1]. Coupling of this derivative can be effected using standard activation methods, such as PyBOP^® or TBTU, although longer reaction times may be necessary due to the bulkiness of the side-chain protection.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] A. S. Verdini, et al. (1992) Tetrahedron Lett., 33, 6541.

Liaison

Replaces: 04-12-1249

Remarque sur l'analyse

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 98.5 % (a/a)
Purity (TLC(011A)): ≥ 95 %
Assay (HPLC, area%): ≥ 91.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 1.5 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable