677181

Vincristine Sulfate, Apocynaceae sp.

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.

• Synonyme(s) : Vincristine Sulfate, Apocynaceae sp.
• Formule empirique (notation de Hill): C₄₆H₅₆N₄O₁₀ · xH₂SO₄
• Numéro CAS: 2068-78-2
• Poids moléculaire : 824.96 (free base basis)
• Numéro MDL: MFCD00084729
• Code UNSPSC : 12352210
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: water: 20 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
• Clé InChI: AQTQHPDCURKLKT-JKDPCDLQSA-N

Description

Description générale

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Indole alkaloid that binds to tubulin, inhibiting the formulation of microtubules. Depolymerizes microtubules. Induces an increase in the micronucleus and delays cell cycle progression. Antineoplastic agent. Induces apoptosis in human lymphoma cells by distributing microtubules.

Actions biochimiques/physiologiques

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Autres remarques

Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H300,H341,H361fd
• Conseils de prudence: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Classification des risques: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable