5.38096

GluN2B NMDA Receptor Antagonist, 93-31

• Synonyme(s) : GluN2B NMDA Receptor Antagonist, 93-31, (S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
• Formule empirique (notation de Hill): C₂₂H₃₀Cl₂N₂O₄S
• Numéro CAS: 457897-98-2
• Poids moléculaire : 489.46
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid (sticky)
• Puissance: 0.19 μM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: light yellow to yellow
• Solubilité: DMSO: 100 mg/mL
• Température de stockage: −20°C

Description

Description générale

A tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC₅₀ = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED₅₀ ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC₅₀ = 70 nM) and alpha1-adrenergic receptor (IC₅₀ = 4.9 µM).

Actions biochimiques/physiologiques

Primary Target
GluN2B NMDA Receptor

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Yuan, H., et al. 2015. Neuron.85, 1305.
Tahirovic, Y., et al. 2008. J. Med. Chem.51, 5506.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable