420210

Jervine

A cell-permeable steroidal alkaloid similar to cyclopamine that displays teratogenic effects and induces cyclopia by blocking Sonic Hedgehog signaling.

• Synonyme(s) : Jervine, (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
• Formule empirique (notation de Hill): C₂₇H₃₉NO₃
• Numéro CAS: 469-59-0
• Poids moléculaire : 425.60
• Numéro MDL: MFCD01684066
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white
• Solubilité: ethanol: 10 mg/mL; DMSO: 5 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• InChI: 1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3
• Clé InChI: CLEXYFLHGFJONT-UHFFFAOYSA-N

Description

Description générale

A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC₅₀ = ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.

A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC₅₀ ~500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Induces cyclopia by blocking shh (Sonic Hedgehog) signaling

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ~ 500-700 nM blocking shh (Sonic Hedgehog) signaling in s12 cells

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Toxic (F)

Notes préparatoires

Slight warming may be required to achieve complete solubilization in ethanol.

Reconstitution

Following reconstitution in fresh DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Williams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA100, 4616.
Cooper, M. K., et al. 2003. Nat. Genet.33, 508.
Mistretta, C.M., 2003. Dev. Biol.254, 1.
ten Berge, D., et al. 2001. Development128, 2929.
Cooper, M.K., et al. 1998. Science280, 1603.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H360D
• Conseils de prudence: P201 - P202 - P264 - P270 - P280 - P301 + P310
• Classification des risques: Acute Tox. 3 Oral - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable