1.02839

L-cystéine hydrochloride monohydrate

for biochemistry

• Synonyme(s) : Cys, L-Cysteinium Chloride Monohydrate, L-Cysteine Hydrochloride, Monohydrate
• Formule linéaire : HSCH₂CH(NH₂)COOH · HCl · H₂O
• Numéro CAS: 7048-04-6
• Poids moléculaire : 175.63
• Numéro Beilstein : 5158059
• Numéro MDL: MFCD00065606
• Code UNSPSC : 12352209
• Numéro de classement CE : 200-157-7
• Nomenclature NACRES : NA.21

Propriétés

• Pression de vapeur: <0.1 hPa ( 20 °C)
• Niveau de qualité: 100
• Pureté: 98.5-101.0% dry basis (alkalimetric)
• Forme: crystalline powder
• pH: 0.8-1.2 (20 °C, 100 g/L in H₂O)
• Pf: 168-170 °C
• Solubilité: 650 g/L
• Densité: 1.54 g/cm³
• Masse volumique apparente: 780 kg/m³
• Traces d'anions: sulfate (SO₄^2-): ≤300 ppm
• Traces de cations: Fe: ≤20 ppm; heavy metals (as Pb): ≤10 ppm
• Température de stockage: 2-30°C
• Chaîne SMILES: O.Cl.N[C@@H](CS)C(O)=O
• InChI: 1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1
• Clé InChI: QIJRTFXNRTXDIP-JIZZDEOASA-N

Description

Application

• Smartphone-based Ellman′s colourimetric methods for the analysis of d-penicillamine formulation and thiolated polymer: Demonstrates the application of L-Cysteine hydrochloride monohydrate in developing colorimetric assays for pharmaceutical analysis, enhancing the accessibility and cost-effectiveness of drug quality control (Phadungcharoen et al., 2019).


• The effects of the thiolation with thioglycolic acid and l-cysteine on the mucoadhesion properties of the starch-graft-poly(acrylic acid): Focuses on the modification of polymers with L-Cysteine hydrochloride monohydrate to improve their mucoadhesive properties, which is critical for developing more effective drug delivery systems (Gök et al., 2017).


• On-line pre-reduction of pentavalent arsenicals by thioglycolic acid for speciation analysis by selective hydride generation-cryotrapping-atomic absorption spectrometry: Utilizes L-Cysteine hydrochloride monohydrate in analytical chemistry techniques to improve the detection and measurement of toxic elements in environmental samples, crucial for monitoring and ensuring public health (Musil et al., 2008).

Actions biochimiques/physiologiques

Il s′agit d′un antagoniste des récepteurs glutamatergiques de type NMDA.

Remarque sur l'analyse

Assay (alkalimetric, calculated on dried substance): 98.5 - 101.0 %
Identity (IR-spectrum): passes test
Identity (Chloride): passes test
Appearance: white or almost white, crystalline powder or colorless crystals
Appearance of solution (25 g/l, water): clear and not more intense in color than reference solution BY6
Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 250 g/l, calc. on dried substance): +5.5 to +7.0
Spec. rotation (α 25/D, 80 g/l, hydrochloric acid 6 mol/l, calc. on dried substance): +5.7 to +6.8
Sulfate (SO₄): ≤ 300 ppm
Heavy metals (as Pb): ≤ 10 ppm
Fe (Iron): ≤ 20 ppm
Related Compounds, total (TLC): ≤ 0.5 %
Ninhydrin-positive substances (LC)(impurity A (570 nm)): ≤ 0.5 %
Ninhydrin-positive substances (LC)(any ninhydrin-positive impurity): ≤ 0.2 %
Ninhydrin-positive substances (LC) (ammonium (570 nm)): ≤ 0.02 %
Ninhydrin-positive substances (LC)(total impurities): ≤ 1.0 %
Residual solvents (ICH Q3C): excluded by manufacturing process
Sulfated ash (600 °C): ≤ 0.1 %
Loss on drying (Vacuum < 0.7 kPa, P₂O₅, 24 h): 8.0 - 12.0 %
Bacterial endotoxins: ≤ 6.0 I.U./g

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable