D-079
Demoxepam solution
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Formule empirique (notation de Hill):
C15H11ClN2O2
Numéro CAS:
Poids moléculaire :
286.71
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
certified reference material
Forme
liquid
Caractéristiques
Snap-N-Spike®/Snap-N-Shoot®
Conditionnement
ampule of 1 mL
Fabricant/nom de marque
Cerilliant®
Concentration
1.0 mg/mL in acetonitrile
Technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
Application(s)
clinical testing
Format
single component solution
Température de stockage
−20°C
Chaîne SMILES
ClC1=CC=C(NC(C[N+]([O-])=C2C3=CC=CC=C3)=O)C2=C1
InChI
1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19)
Clé InChI
GGRWZBVSUZZMKS-UHFFFAOYSA-N
Description générale
A benzodiazepine drug and anticonvulsant, demoxepam is also a primary metabolite of chlordiazepoxide, marketed as Klopoxid or Librax® for the treatment of anxiety and muscle spasms or pain.
Application
- Pharmacokinetic and Pharmacodynamic Analysis: A study discussed the rapid hydrolysis of chlordiazepoxide to Demoxepam, emphasizing the importance of understanding metabolic pathways in benzodiazepine analogues research. This knowledge aids in the design of neuropharmacology experiments and the development of GABA receptor agonist studies (Vinkers et al., 2010).
- Neuropharmacological Studies: Research utilizing Demoxepam has explored its role as a benzodiazepine receptor ligand, which provides insight into its function as a neuropharmacology research chemical. These studies contribute to our understanding of Demoxepam′s effects on anxiety and its potential therapeutic applications (Lister et al., 1984).
- High-Performance Liquid Chromatography (HPLC) Applications: The application of HPLC in the determination of 1,4-benzodiazepines and their metabolites, including Demoxepam, highlights its utility in the precise measurement of these compounds in plasma. This is crucial for biochemical assays and enhances the research reagent′s reliability in pharmaceutical industry studies (Skellern et al., 1978).
Informations légales
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Librax is a registered trademark of Valeant Pharmaceuticals North America LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Code de la classe de stockage
3 - Flammable liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
35.6 °F - closed cup
Point d'éclair (°C)
2 °C - closed cup
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
A G Davidson
Journal of pharmaceutical sciences, 73(1), 55-58 (1984-01-01)
Rapid difference spectrophotometric methods for chlordiazepoxide and demoxepam in chlordiazepoxide formulations are described which overcome the nonspecificity of the official spectrophotometric assays. The procedures are based on the measurement of the difference absorbance at 269 nm of equimolar solutions of
H Sidransky et al.
Biochemical medicine and metabolic biology, 47(3), 270-273 (1992-06-01)
Since some patients with eosinophilia-myalgia syndrome ingested tryptophan along with benzodiazepines, we investigated whether demoxepam, the N-desalkylated compound of chlordiazepoxide, would influence the binding of tryptophan to hepatic nuclei. L-Tryptophan has been shown to bind (saturable, stereospecific, and of high
Moustapha Ouédraogo et al.
Drug and chemical toxicology, 32(4), 417-423 (2009-10-02)
The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and its metabolites was investigated in vitro by a MTT assay on P388 leukemia and B16 melanoma cell lines and compared with that of the anticancer drug, melphalan. For the
H Essien et al.
Journal of chromatography. B, Biomedical applications, 683(2), 199-208 (1996-08-30)
The identification of the metabolite demoxepam in human urine establishes that chlordiazepoxide, a common benzodiazepine, has been administered. Like N-oxide metabolites of other drugs, demoxepam cannot be detected by gas chromatography-mass spectrometry (GC-MS), due to thermal decomposition, and the product
T J Good et al.
Journal of chromatographic science, 19(11), 562-566 (1981-11-01)
A simple, rapid method for the determination of the benzodiazepines, diazepam and chlordiazepoxide, and their metabolites by high performance liquid chromatography (HPLC) has been developed. The procedure is applicable to the assay of other similar drugs in biological fluids. The
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