D-034

Dextrorphan tartrate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₂₁H₂₉NO₇
• Numéro CAS: 143-98-6
• Poids moléculaire : 407.46
• Numéro CE : 200-659-6
• Numéro MDL: MFCD00151495
• Code UNSPSC : 41116107
• ID de substance PubChem : 329798600
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 1.0 mg/mL in methanol (as free base)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34
• InChI: 1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m11/s1
• Clé InChI: RWTWIZDKEIWLKQ-XCPWPWHNSA-N

Description

Description générale

A Snap-N-Spike^® Reference Solution suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, P450 trials, or pharmaceutical research. Dextrorphan is a primary metabolite of dextromethorphan in blood. Dextromethorphan, an active ingredient in many over-the-counter cold and cough medicines, is used recreationally as a hallucinogen with effects similar to ketamine and phencyclidine (PCP).

Application

• Anti-Persister Activity Against Borrelia burgdorferi: Dextrorphan tartrate was evaluated for its anti-persister activity against Borrelia burgdorferi, demonstrating potential as an effective agent in the treatment of persistent Lyme disease infections. This research underscores its pharmacodynamic relevance and encourages further exploration in neuropharmacological contexts (Feng et al., 2015).


• High-Performance Liquid Chromatography in Pharmacokinetics: Dextrorphan tartrate was used in a sensitive assay involving high-performance liquid chromatography for the detection of metoprolol and its major metabolite in human plasma. This method highlights its importance as an analytical standard in pharmacokinetic studies, aiding in the understanding of drug metabolism and disposition (Mistry et al., 1998).


• Opioid Receptor Binding: The interaction of dextrorphan tartrate with opioid receptors was examined, showing that it binds to opioid receptors in guinea-pig brain membranes and acts as an antagonist in myenteric plexus. This research supports its utility in opioid receptor studies, particularly in examining opioid antagonistic properties (Goldstein & Naidu, 1990).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup