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Key Documents

800742C

Avanti

N-20:4 L-Serine (ARA-S)

N-arachidonoyl L-serine, chloroform

Synonyme(s) :

ARA-S; 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine; (S)-3-hydroxy-2-(5Z,8Z,11Z,14Z)-eicosatetraenamidopropanoate; (S)-3-hydroxy-2-arachidonamidopropanoate

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About This Item

Formule empirique (notation de Hill):
C23H37NO4
Numéro CAS:
1246355-55-4
Poids moléculaire :
391.54
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

liquid

Conditionnement

pkg of 1 × 1 mL (800742C-5mg)

Fabricant/nom de marque

Avanti Polar Lipids 800742C

Concentration

5 mg/mL (800742C-5mg)

Type de lipide

bioactive lipids
phosphoglycerides

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

N-20:4 L-Serine (ARA-S), a unique lipoamino acid is endogenous in nature. It is localized to the brain. It has structural resemblance with anandamide, an endocannabinoid.

Actions biochimiques/physiologiques

N-20:4 L-Serine (ARA-S) is a signaling lipid that regulates neuronal-type Ca2+ channels in the brain. ARA-S is known to produce endothelium-dependent arterial vasodilatation in vitro. It is also found to exert neuroprotective action following brain injury.

Conditionnement

5 mL Clear Glass Sealed Ampule (800742C-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

does not flash

Point d'éclair (°C)

does not flash

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Esther Shohami et al.
British journal of pharmacology, 163(7), 1402-1410 (2011-03-23)
Traumatic brain injury (TBI) represents the leading cause of death in young individuals. It triggers the accumulation of harmful mediators, leading to secondary damage, yet protective mechanisms are also set in motion. The endocannabinoid (eCB) system consists of ligands, such
Grzegorz Godlewski et al.
The Journal of pharmacology and experimental therapeutics, 328(1), 351-361 (2008-10-17)
The novel endocannabinoid-like lipid N-arachidonoyl L-serine (ARA-S) causes vasodilation through both endothelium-dependent and -independent mechanisms. We have analyzed the vasorelaxant effect of ARA-S in isolated vascular preparations and its effects on Ca(2+)-activated K(+) currents in human embryonic kidney cells stably
Seung-Yeol Park et al.
Nature communications, 10(1), 3409-3409 (2019-08-01)
Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage
Suguru Komenoi et al.
FEBS letters, 589(11), 1272-1277 (2015-04-12)
Diacylglycerol kinase (DGK) η plays important roles in various patho-physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The Km value for diacylglycerol was 0.14 mol%. Intriguingly, the Km value

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