861650

(+)-Biotin 4-nitrophenyl ester

98%

• Synonyme(s) : 4-Nitrophenyl (+)-biotinate, d-Biotin p-nitrophenyl ester, BNP
• Formule empirique (notation de Hill): C₁₆H₁₉N₃O₅S
• Numéro CAS: 33755-53-2
• Poids moléculaire : 365.40
• Numéro Beilstein : 5795805
• Numéro MDL: MFCD15141972
• Code UNSPSC : 12352108
• ID de substance PubChem : 24888552
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Pureté: 98%
• Forme: powder
• Activité optique: [α]25/D +51°, c = 2 in DMF: AcOH (99:1)
• Pf: 163-165 °C (lit.)
• Solubilité: methanol: 25 mg/mL, clear, colorless to greenish-yellow
• Chaîne SMILES: [O-][N+](=O)c1ccc(OC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1
• InChI: 1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
• Clé InChI: YUDNXDTXQPYKCA-YDHLFZDLSA-N

Description

Application

(+)-Biotin 4-nitrophenyl ester may be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies. It may also be used to prepare biotinylated quinazoline derivatives, which shows inhibitory activities against VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinase. (+)-Biotin 4-nitrophenyl ester undergoes hydrolysis in the presence of Na[¹⁷O]H to form [¹⁷O₂]biotin, which can be used in solid-state ¹⁷O NMR spectroscopic experiments to analyze large protein-ligand complexes.

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Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)