804568

(R,S)-Bode Kinetic Resolution Catalyst

• Synonyme(s) : (4aR,9aS)-6-Bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one
• Formule empirique (notation de Hill): C₁₁H₁₀BrNO₃
• Numéro CAS: 1394957-71-1
• Poids moléculaire : 284.11
• Code UNSPSC : 12352101
• ID de substance PubChem : 329768882
• Nomenclature NACRES : NA.22

Propriétés

• Forme: solution
• Niveau de qualité: 100
• Groupe fonctionnel: bromo; ether
• Température de stockage: 15-25°C
• Chaîne SMILES: O=C(CO1)N(O)[C@@]2([H])[C@]1([H])CC3=CC=C(Br)C=C32
• InChI: 1S/C11H10BrNO3/c12-7-2-1-6-3-9-11(8(6)4-7)13(15)10(14)5-16-9/h1-2,4,9,11,15H,3,5H2/t9-,11+/m0/s1
• Clé InChI: FQXSUQCCAHKURK-GXSJLCMTSA-N

Description

Application

The following hydroxamic acid catalyst was shown by Bode and coworkers to assist in the kinetic resolution of cyclic amines through acylation of one enantiomer, which can be controlled using either the (R or S)- or (S or R)-Bode Kinetic Resolution Catalyst, both of which are also available through Sigma-Aldrich.
It can also be employed in the preparation of nonracemic piperidines by kinetic resolution using an α-hydroxy-α′, β-unsaturated ketone in the presence of a pyrrolotriazolium salt.

Autres remarques

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable