798436

Endo-1-Naphthyl Kwon [2.2.1] Bicyclic Phosphine

• Synonyme(s) : (1S,4S,5S)-5-(naphthalen-1-yl)-2-tosyl-2-aza-5-phosphabicyclo[2.2.1]heptane
• Formule empirique (notation de Hill): C₂₂H₂₂NO₂PS
• Poids moléculaire : 395.45
• Numéro MDL: MFCD28016349
• Code UNSPSC : 12352000
• ID de substance PubChem : 329768649
• Nomenclature NACRES : NA.22

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Conditions de stockage: under inert gas
• Groupe fonctionnel: phosphine; sulfonamide
• Température de stockage: 2-8°C
• Chaîne SMILES: O=S(N1C[C@H]2[P@@](C3=CC=CC4=C3C=CC=C4)C[C@@H]1C2)(C5=CC=C(C)C=C5)=O
• InChI: 1S/C22H22NO2PS/c1-16-9-11-20(12-10-16)27(24,25)23-14-19-13-18(23)15-26(19)22-8-4-6-17-5-2-3-7-21(17)22/h2-12,18-19H,13-15H2,1H3
• Clé InChI: RGHUOMJULXTHPX-UHFFFAOYSA-N

Description

Application

The bicyclic, chiral phosphine was developed by the Kwon Research Group. Its initial applications were for asymmetric [3+2] annulation between allenes and imines as well as the first examples of phosphine-catalyzed asymmetric syntheses of 1,2,3,5-substituted pyrrolines. Along with nucleophilic organocatalysis, the P-chiral phosphines may also find utility in asymmetric transition-metal catalysis.

Autres remarques

Hydroxyproline-Derived Pseudoenantiomeric [2.2.1] Bicyclic Phosphines: Asymmetric Synthesis of (+)- and (-)-Pyrrolines

Technology Spotlight- Kwon Phosphines: P-Chiral Monodentate Phosphines from Hydroxyproline

Aldrichimica Acta Review- Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric Annulations

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable