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729159

Sigma-Aldrich

Poly(ethylene glycol) methyl ether thiol

average MN 6,000, chemical modification reagent thiol reactive, methoxy, thiol

Synonyme(s) :

Polyethylene glycol, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, PEG thiol, mPEG thiol

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About This Item

Formule linéaire :
CH3O(CH2CH2O)nCH2CH2SH
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

product name

Poly(ethylene glycol) methyl ether thiol, average Mn 6,000

Forme

solid

Niveau de qualité

100

Poids mol.

average Mn 6,000

Pertinence de la réaction

reagent type: chemical modification reagent
reactivity: thiol reactive

Pf

56-61 °C

Mw/Mn

≤1.2

Extrémité Ω

thiol

Extrémité α

methoxy

Architecture des polymères

shape: linear
functionality: monofunctional

Conditions d'expédition

dry ice

Température de stockage

−20°C

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Description générale

Poly(ethylene glycol) methyl ether thiol (mPEGthiol) is a thiol-terminated biocompatible polymer widely used in the surfacefunctionalization of gold nanoparticles. Thiol moieties bind with high affinityto gold surfaces by forming a self-assembled monolayer (SAM) through thecovalent thiolate–metal bond. mPEG thiol-coated Au nanoparticles findapplication in the fields of biosensors and drug delivery systems.

Application

Poly(ethylene glycol) methyl ether thiol-coated Au nanoparticles can be used for the determination of melamine T. by an optical method. It can also be used to fabricate switchable super-wetting membranes foroil/water separation.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MKCL4582
MKCH0719
MKCF5112
MKBW7623V
MKBS3186V

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Consulter la Bibliothèque de documents

Amina Ghorbel et al.
Bioelectrochemistry (Amsterdam, Netherlands), 137, 107642-107642 (2020-09-28)
The use of conductive nanoparticles (NPs) was previously proposed as a way to locally amplify the electric field (EF) intensity at the cell membrane to enhance cell electroporation. To achieve this, a close distance between the NPs and the cell
Jairo Pinto Oliveira et al.
Scientific reports, 9(1), 13859-13859 (2019-09-27)
Antibody-coated nanoparticles have recently attracted considerable attention, with the focus falling on diagnostics. Nevertheless, controlled antibody bioconjugation remains a challenge. Here, we present two strategies of bioconjugation with the aim of evaluating the best approach for the coupling of antibodies

Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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