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643440

Sigma-Aldrich

L-Arginine-13C6 hydrochloride

99 atom % 13C, 95% (CP)

Synonyme(s) :

SILAC Amino Acid, (S)-(+)-2-Amino-5-[(aminomethyl)amino]pentanoic acid-13C6 hydrochloride, 13C Labeled arginine, 13C Labeled arginine hydrochloride

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About This Item

Formule linéaire :
H2N13C(NH)NH13CH2(13CH2)213CH(NH2)13CO2H · HCl
Numéro CAS:
201740-91-2
Poids moléculaire :
216.62
Numéro MDL:
MFCD00144558
Code UNSPSC :
12352209
ID de substance PubChem :
24883267
Nomenclature NACRES :
NA.12

Pureté isotopique

99 atom % 13C

Niveau de qualité

200

Pureté

95% (CP)

Forme

solid

Activité optique

[α]20/D +22°, c = 12 in 10% HCl

Technique(s)

protein expression: suitable

Pf

226-230 °C (dec.) (lit.)

Changement de masse

M+6

Chaîne SMILES 

Cl[H].N[13C@@H]([13CH2][13CH2][13CH2]N[13C](N)=N)[13C](O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1;

Clé InChI

KWTQSFXGGICVPE-BJPSCUOKSA-N

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Application

Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages. Identification of viral proteins from coronavirus infectious bronchitis-infected cells has been achieved with Stable Isotope labeling in conjunction with LC-MS/MS.

Conditionnement

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MBBD0213
MBBB4331V
CC0340
TA0298V
SZ2006

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Gino L Turra et al.
Microbiology spectrum, 9(2), e0080921-e0080921 (2021-09-30)
Import and oxidative folding of proteins in the mitochondrial intermembrane space differ among eukaryotic lineages. While opisthokonts such as yeast rely on the receptor and oxidoreductase Mia40 in combination with the Mia40:cytochrome c oxidoreductase Erv, kinetoplastid parasites and other Excavata/Discoba
Stephanie D Kraft-Terry et al.
Journal of proteome research, 10(6), 2852-2862 (2011-04-20)
Dynamic interactions between human immunodeficiency virus-1 (HIV-1) and the macrophage govern the tempo of viral dissemination and replication in its human host. HIV-1 affects macrophage phenotype, and the macrophage, in turn, can modulate the viral life cycle. While these processes
Zehan Hu et al.
Cell reports, 28(13), 3486-3496 (2019-09-26)
The target of rapamycin complex 1 (TORC1) is a master regulator of cell homeostasis, which promotes anabolic reactions and synchronously inhibits catabolic processes such as autophagy-mediated protein degradation. Its prime autophagy target is Atg13, a subunit of the Atg1 kinase
Koshi Imami et al.
Molecular cell, 72(1), 84-98 (2018-09-18)
Emerging evidence indicates that heterogeneity in ribosome composition can give rise to specialized functions. Until now, research mainly focused on differences in core ribosomal proteins and associated factors. The effect of posttranslational modifications has not been studied systematically. Analyzing ribosome
Ye Dee Tay et al.
Cell reports, 26(6), 1654-1667 (2019-02-07)
NDR/LATS kinases regulate multiple aspects of cell polarity and morphogenesis from yeast to mammals. Fission yeast NDR/LATS kinase Orb6 has been proposed to control cell polarity by regulating the Cdc42 guanine nucleotide exchange factor Gef1. Here, we show that Orb6

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Protein Structural Analysis

Protein structure provides valuable information that can be used to infer protein function. The study of protein structure and mapping of protein interactions, expression levels, and location enables the identification of disease biomarkers and potential drug targets for therapeutic treatment.

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