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136565

Sigma-Aldrich

N-(3-Aminopropyl)-2-pyrrolidinone

technical grade

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About This Item

Formule empirique (notation de Hill):
C7H14N2O
Numéro CAS:
7663-77-6
Poids moléculaire :
142.20
Numéro CE :
231-632-7
Numéro MDL:
MFCD00003201
Code UNSPSC :
12352100
ID de substance PubChem :
24848286
Nomenclature NACRES :
NA.22

Qualité

technical grade

Forme

liquid

Impuretés

2% 2-pyrrolidinone

Indice de réfraction

n20/D 1.5 (lit.)

Point d'ébullition

120-123 °C/1 mmHg (lit.)

Densité

1.014 g/mL at 25 °C (lit.)

Chaîne SMILES 

NCCCN1CCCC1=O

InChI

1S/C7H14N2O/c8-4-2-6-9-5-1-3-7(9)10/h1-6,8H2

Clé InChI

HJORCZCMNWLHMB-UHFFFAOYSA-N

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Description générale

N-(3-Aminopropyl)-2-pyrrolidinone (PYR) conjugates (VPA-PYR) of valproic acid (VA) have been investigated for their anticonvulsant activity in mice. It is the γ-lactam form of isoputreanine.

Application

N-(3-Aminopropyl)-2-pyrrolidinone was used in the simultaneous determination of total polyamines and three of their non−α− amino acid metabolites in urine by capillary gas-chromatographic method with nitrogen-phosphorus detection.

Autres remarques

Contains varying amounts of 1,5-diazabicyclo[4.3.0]non-5-ene (cat. no. 136581)

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H314

Classification des risques

Skin Corr. 1B

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

235.4 °F - closed cup

Point d'éclair (°C)

113 °C - closed cup

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

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Ofer Spiegelstein et al.
Epilepsy research, 57(2-3), 145-152 (2004-03-12)
Valproic acid (VPA) is an effective antiepileptic medication, the use of which in females of childbearing age is complicated by its ability to induce birth defects, including neural tube defects (NTDs), in exposed embryos. In experimental settings, VPA reproducibly induces
N Seiler et al.
The Biochemical journal, 208(1), 189-197 (1982-10-15)
A high-pressure-liquid-chromatographic method suitable for the separation and sensitive detection of putreanine and isoputreanine is described. This method allowed us to study the formation of the metabolites of the oxidative deamination of spermidine and N1-acetylspermidine. Administration of spermidine trishydrochloride to
N Seiler et al.
The International journal of biochemistry, 15(7), 907-915 (1983-01-01)
Normal human and rat urine contain N-(3-aminopropyl)pyrrolidin-2-one. This compound was identified by its chromatographic behaviour on a reversed phase column, by thin-layer chromatography of its dansyl derivative, and by mass spectrometry. Evidence for the presence of conjugates of N-(3-aminopropyl)pyrrolidin-2-one in
Andre P Martinez et al.
Biomacromolecules, 18(6), 2000-2011 (2017-05-20)
A series of biodegradable drug delivery polymers with intrinsic multifunctionality have been designed and synthesized utilizing a polyphosphazene macromolecular engineering approach. Novel water-soluble polymers, which contain carboxylic acid and pyrrolidone moieties attached to an inorganic phosphorus-nitrogen backbone, were characterized by
F A Muskiet et al.
Clinical chemistry, 30(5), 687-695 (1984-05-01)
A capillary gas-chromatographic method with nitrogen-phosphorus detection is used here to simultaneously determine 1,3-diaminopropane, putrescine, cadaverine, spermidine, spermine, isoputreanine , putreanine , and N-(3-aminopropyl)-N'-(2-carboxyethyl)-1,4- diaminobutane in urine. After acid hydrolysis the compounds are isolated by adsorption onto silica gel and

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