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  • High-performance liquid chromatographic enantioseparation of bicalutamide and its related compounds.

High-performance liquid chromatographic enantioseparation of bicalutamide and its related compounds.

Journal of chromatography. A (2005-11-30)
Roland Török, Adám Bor, György Orosz, Ferenc Lukács, Daniel W Armstrong, Antal Péter
ZUSAMMENFASSUNG

Direct high-performance liquid chromatographic methods were developed for the enantioseparation of (R,S)-bicalutamide (1) and its analogs (+/-)-3-chloro-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide (2), (+/-)-N-(4-cyano-3-(trifluoro-methyl)phenyl)-2-methyloxirane-2-carboxamide (3), (+/-)-4-fluorophenylsulfonyl-2-hydroxy-2-methylpropionic acid (4) and (+/-)-3-hydroxy-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide (5). The methods involved the use of a cellulose-based Chiralcel OD-H, macrocyclic glycopeptide-based Chirobiotic T, TAG and R, beta-cyclodextrin-based Cyclobond I 2000SN and t-butyl carbamate-derivatized quinine-based columns. The conditions affording the best resolution were found by selection and variation of the mobile-phase compositions, and the differences in separation capability of the methods were noted. The sequence of elution of the enantiomers was determined in all cases.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® CYCLOBOND I 2000 Chirale HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® V Chirale HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
HPLC-Säule Astec® CHIROBIOTIC® TAG chiral, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® Cyclobond I 2000 HP-RSP Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® Chirobiotic® R Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® Chirobiotic® R Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
HPLC-Säule Astec® CHIROBIOTIC® TAG chiral, 5 μm particle size, L × I.D. 25 cm × 21.2 mm
Supelco
Astec® Chirobiotic® R Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
HPLC-Säule Astec® CHIROBIOTIC® TAG chiral, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Astec® Cyclobond I 2000 HP-RSP Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Astec® CYCLOBOND I 2000 Chirale HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 10 mm
Supelco
Astec® CHIROBIOTIC® V Chirale HPLC-Säule, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
Astec® Chirobiotic® R Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
Astec® CYCLOBOND I 2000 Chirale HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® V Chirale HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 5 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 10 mm
Supelco
Astec® CYCLOBOND I 2000 Chirale HPLC-Säule, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® V Chirale HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
HPLC-Säule Astec® CHIROBIOTIC® TAG chiral, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
Supelco
Astec® Chirobiotic® R Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® T Chirale HPLC-Säule, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
HPLC-Säule Astec® CHIROBIOTIC® TAG chiral, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
HPLC-Säule Astec® CHIROBIOTIC® TAG chiral, 5 μm particle size, L × I.D. 25 cm × 10 mm
Supelco
Astec® CHIROBIOTIC® V Chirale HPLC-Säule, 5 μm particle size, L × I.D. 10 cm × 2.1 mm