V900890

Streptozocin

Vetec^™, reagent grade, 98%, powder

• Synonym(e): N-(Methylnitrosocarbamoyl)-α-D-glucosamin, Streptozotocin
• Empirische Formel (Hill-System): C₈H₁₅N₃O₇
• CAS-Nummer: 18883-66-4
• Molekulargewicht: 265.22
• Beilstein: 2060675
• MDL-Nummer: MFCD00006607
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329830222

Eigenschaften

• Qualität: reagent grade
• Produktlinie: Vetec^™
• Assay: 98%
• Form: powder
• mp (Schmelzpunkt): 121 °C (dec.) (lit.)
• Lagertemp.: −20°C
• SMILES String: CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
• InChI: 1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
• InChIKey: ZSJLQEPLLKMAKR-GKHCUFPYSA-N

Beschreibung

Allgemeine Beschreibung

Streptozocin (STZ or 2-deoxy-2(3-methyl-3-nitrosoureido)-d-glucopyranose), an antibiotic, is primarily isolated from Streptomyces achromogenes.

Anwendung

Streptozocin has been used:

• to treat mice intraperitoneally for the animal experiments
• in sodium citrate buffer to treat mice intraperitoneally for in vivo STZ treatment to perform single-cell RNA sequencing of pancreatic endocrine cells
• to induce diabetes/diabetic retinopathy (DR) in mice to study the role of microglial spleen tyrosine kinase (Syk) in DR

Biochem./physiol. Wirkung

Eine N-Nitroso-Verbindung, die als Stickoxidspender in Langerhans′schen Inseln fungiert; induziert den Tod Insulin-sezernierender Zellen und produziert ein Tiermodell von Diabetes. Starkes DNA-Methylierungsmittel, das Chromosomenbruch induziert. Zytotoxisch für neuroendokrine Tumorzelllinien, die den GLUT2-Glucosetransporter exprimieren.

Streptozocin (STZ or 2-deoxy-2(3-methyl-3-nitrosoureido)-d-glucopyranose), a potent alkylating agent, resulting in pancreatic β-cell destruction, is used as an agent to induce insulin-dependent diabetes mellitus (IDDM) experimentally. It exhibits oncolytic, anti-tumor, oncogenic, and diabetogenic properties. This antineoplastic agent is used in the treatment of metastatic pancreatic islet cell carcinoma. STZ can directly methylate DNA and is highly genotoxic.

Rechtliche Hinweise

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS08
• Signalwort: Warning
• H-Sätze: H228,H341,H351
• P-Sätze: P201 - P202 - P210 - P240 - P241 - P308 + P313
• Gefahreneinstufungen: Carc. 2 - Flam. Sol. 2 - Muta. 2
• Lagerklassenschlüssel: 4.1B - Flammable solid hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable