D6821

Donepezil hydrochloride

≥98% (HPLC)

• Synonym(e): 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, E2020
• Empirische Formel (Hill-System): C₂₄H₂₉NO₃ · HCl
• CAS-Nummer: 120011-70-3
• Molekulargewicht: 415.95
• MDL-Nummer: MFCD00881312
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798838
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Löslichkeit: DMSO: ≥20 mg/mL; H₂O: ≥20 mg/mL
• Lagertemp.: room temp
• SMILES String: O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl
• InChI: 1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
• InChIKey: HLJIZAKUNCTCQX-UHFFFAOYSA-N
• Angaben zum Gen: human ... ACHE(43)

Beschreibung

Anwendung

Donepezil hydrochloride has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice. It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity.

Biochem./physiol. Wirkung

Donepezil hydrochloride is a piperidine containing an organic compound and a non-competitive inhibitor. It is useful in treating Alzheimer′s disease, in which dementia is a prominent symptom. Donepezil is shown to induce cognitive ability and overall body function. It has a half-life of 70 hours.

Donepezil monohydrochloride monohydrate is a centrally acting reversible acetylcholinesterase inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300 - H319
• P-Sätze: P264 - P270 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Acute Tox. 2 Oral - Eye Irrit. 2
• Lagerklassenschlüssel: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable