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Merck

1249406

USP

Escitalopram -oxalat (Salz)

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

(S)-(+)-1-[3-(Dimethylamino)-propyl]-1-(4-fluorphenyl)-1,3-dihydro-5-isobenzofurancarbonitril -oxalat (Salz), (S)-(+)-Citalopram -oxalat (Salz)

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About This Item

Empirische Formel (Hill-System):
C20H21FN2O · C2H2O4
CAS-Nummer:
Molekulargewicht:
414.43
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

escitalopram, escitalopram

Hersteller/Markenname

USP

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1

InChIKey

KTGRHKOEFSJQNS-BDQAORGHSA-N

Angaben zum Gen

human ... SLC6A4(6532)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Escitalopram oxalate, the S-enantiomer of racemic citalopram, belongs to the class of compounds known as antidepressants, that works as a selective serotonin-reuptake inhibitor (SSRI).

Anwendung

Escitalopram oxalate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Escitalopram Oral Solution
  • Escitalopram Oxalate
  • Escitalopram Tablets

Biochem./physiol. Wirkung

Escitalopram is a selective serotonin reuptake inhibitor (SSRI), the S-enantiomer and eutomer of citalopram.

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Dermal - Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Spectrophotometric and reversed-phase high-performance liquid chromatographic methods for simultaneous determination of escitalopram oxalate and clonazepam in combined tablet dosage form
Gandhi VS, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 91(1), 33-38 (2008)
Dietmar Hestermann et al.
Behavioural brain research, 273, 155-165 (2014-07-22)
Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has
Kristan A Leech et al.
Journal of neurotrauma, 31(15), 1334-1342 (2014-04-20)
Incomplete spinal cord injury (iSCI) often results in significant motor impairments that lead to decreased functional mobility. Loss of descending serotonergic (5HT) input to spinal circuits is thought to contribute to motor impairments, with enhanced motor function demonstrated through augmentation
Simultaneous HPTLC determination of escitalopram oxalate and clonazepam in combined tablets.
Dhavale N, et al.
Chromatographia, 67(5-6), 487-490 (2008)
Gabriel Nowak et al.
Neuropharmacology, 84, 46-51 (2014-05-07)
Metabotropic glutamate 5 (mGlu5) receptors are functionally connected with NMDA receptors. The antidepressant activity of the NMDA receptor antagonist ketamine in both preclinical and clinical studies, along with the antidepressant-like activities of negative allosteric modulators (NAMs) of mGlu5, led us

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