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X4875
Xanthinoxidase aus Kuhmilch
Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein
Synonym(e):
XOD, Xanthine:oxygen oxidoreductase
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About This Item
CAS-Nummer:
EC-Nummer:
1.17.3.2.
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352204
NACRES:
NA.54
Empfohlene Produkte
Biologische Quelle
bovine milk
Qualitätsniveau
Typ
Grade IV
Form
ammonium sulfate suspension
Spezifische Aktivität
≥0.1 units/mg protein
Lagertemp.
2-8°C
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Allgemeine Beschreibung
Research area: Cell CycleXanthineoxidase (XO) is a homodimer. It is made up of two sub-units each made up of onemolybdenum and two iron-sulphur (2Fe-2S) centers.
Frühere EG-Nummer 1.1.3.22
Anwendung
Xanthine Oxidase from bovine milk has been used in superoxide dismutaseactivity assay.Xanthine oxidase may be suitable for producing amperometric biosensors and designing-flavonoid-type inhibitors against XO for treating inflammatory diseases, gout, and hyperuricemia. It may also be used in the synthesis of superoxide because of aldehyde oxidation.
Biochem./physiol. Wirkung
Xanthinoxidase ist ein molybdänhaltiges Enzym, das im Zytosol vorkommt und durch Flavonoide stark gehemmt werden kann. Es spielt eine wesentliche Rolle beim Metabolismus einiger Arzneimittel sowie von Purinen und Pyrimidinen. Es ist auch eine biologische Quelle für reaktive Sauerstoffspezies.
Although xanthine oxidase is found widely distributed in multiple tissues, it is highly expressed in endothelial and epithelial cells. Its expression was also increased in infected tissues where it was shown to have an anti-microbial effect due to its ability to generate reactive oxygen species. Xanthineoxidase plays an important role in catalyzing the hydroxylation ofhypoxanthine to Xanthine. Later, xanthine is converted to uric acid isexcreted by the kidneys.
Einheitendefinition
One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.
Physikalische Form
Suspension in 2.3 M (NH4)2SO4 containing 1 mM sodium salicylate
Hinweis zur Analyse
Protein determined by biuret
Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Resp. Sens. 1
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Instructions for working with enzymes supplied as ammonium sulfate suspensions
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