T8826

Terbinafin -hydrochlorid

• Synonym(e): trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamin -hydrochlorid
• Empirische Formel (Hill-System): C₂₁H₂₅N · HCl
• CAS-Nummer: 78628-80-5
• Molekulargewicht: 327.89
• MDL-Nummer: MFCD00145430
• UNSPSC-Code: 51302503
• PubChem Substanz-ID: 329826887
• NACRES: NA.85

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: methanol: soluble 50 mg/mL
• Wirkungsspektrum von Antibiotika: fungi; yeast
• Wirkungsweise: enzyme | inhibits
• SMILES String: Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C
• InChI: 1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
• InChIKey: BWMISRWJRUSYEX-SZKNIZGXSA-N

Beschreibung

Allgemeine Beschreibung

Allylamin-Derivat.

Anwendung

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Biochem./physiol. Wirkung

Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.

Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Haftungsausschluss

The product is not intendedfor use as a biocide under global biocide regulations, including but notlimited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, EuropeanBiocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’sBiocidal Products Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H315,H319,H335,H410
• P-Sätze: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves