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T8325
TDZD-8
≥98% (HPLC), needles
Synonym(e):
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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About This Item
Empirische Formel (Hill-System):
C10H10N2O2S
CAS-Nummer:
Molekulargewicht:
222.26
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Qualitätsniveau
Assay
≥98% (HPLC)
Form
needles
Lagerbedingungen
protect from light
Farbe
white
mp (Schmelzpunkt)
63-64.4 °C
Löslichkeit
DMSO: >10 mg/mL
Lagertemp.
2-8°C
SMILES String
CN1SC(=O)N(Cc2ccccc2)C1=O
InChI
1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChIKey
JDSJDASOXWCHPN-UHFFFAOYSA-N
Anwendung
TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.
Biochem./physiol. Wirkung
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.
Leistungsmerkmale und Vorteile
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Angaben zur Herstellung
TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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