T2576

Monoclonal Anti-TIS7 antibody produced in mouse

~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-Interferon-Related Developmental Regulator 1 (IFRD1) (human), Anti-PC4 (rat), Anti-TPA-Induced Sequence 7 (mouse)
• MDL-Nummer: MFCD08705605
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: IRT537, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~50 kDa
• Speziesreaktivität: mouse, human
• Konzentration: ~2 mg/mL
• Methode(n): immunocytochemistry: suitable; indirect ELISA: suitable; microarray: suitable; western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7
• Isotyp: IgG2a
• UniProt-Hinterlegungsnummer: O00458
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... IFRD1(3475) ; mouse ... Ifrd1(15982) ; rat ... Ifrd1(29596)

Beschreibung

Allgemeine Beschreibung

The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.

Immunogen

synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.

Anwendung

Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.

Biochem./physiol. Wirkung

Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable