SRP8050

Profilin from Toxoplasma gondii

recombinant, expressed in E. coli, >95% (SDS-PAGE)

• Synonym(e): Inflammatory profilin, T Cell Membrane Protein 1
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: Toxoplasma gondii
• Rekombinant: expressed in E. coli
• Assay: >95% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~20 kDa by SDS-PAGE
• Verpackung: pkg of 10 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: <0.01 EU/μg endotoxin, tested
• Farbe: white
• UniProt-Hinterlegungsnummer: Q58NA1
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: Toxoplasma gondii ... PRF(7900190)

Beschreibung

Biochem./physiol. Wirkung

Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.

Physikalische Form

Lyophilized from PBS.

Rekonstituierung

Reconstitute with 100 μL deionized water.

Sonstige Hinweise

Recombinant profilin (Toxoplasma gondii) (aa 1-163).

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable