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Wichtige Dokumente

SRP6374

Sigma-Aldrich

Galectin-9 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(e):

Ecalectin, Gal-9, LGALS9, Tumor antigen HOM-HD-21

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About This Item

UNSPSC-Code:
12352200
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

Form

liquid

Mol-Gew.

18.5 kDa (168 aa, 1-148 aa + His Tag.)

Verpackung

pkg of 50 μg

Konzentration

0.5 mg/mL

UniProt-Hinterlegungsnummer

O00182

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... LGALS9(3965)

Allgemeine Beschreibung

Galectin-9 (Gal-9) is a member of animal lectins that have an affinity to β-galactosides and Forssman pentasaccharide. It is strongly overexpressed in Hodgkin′s disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. Recombinant Galectin-9 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Physikalische Form

0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM NaCl and 20% glycerol.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Judith Leitner et al.
PLoS pathogens, 9(3), e1003253-e1003253 (2013-04-05)
T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and
Anthony L Steichen et al.
PloS one, 10(4), e0123573-e0123573 (2015-04-22)
Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis. Here we show that Galectin-9, a host endogenous β-galactoside
R Mukherjee et al.
Food & function, 10(1), 33-37 (2019-01-12)
Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ
Elizabeth Ann L Enninga et al.
The Journal of pathology, 245(4), 468-477 (2018-05-08)
In patients with metastatic melanoma, high blood levels of galectin-9 are correlated with worse overall survival and a bias towards a Th2 inflammatory state supportive of tumor growth. Although galectin-9 signaling through TIM3 on T cells has been described, less
Susanna Leskela et al.
PloS one, 10(4), e0123938-e0123938 (2015-04-17)
Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with AITD. Peripheral blood samples from 25 patients with
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