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Merck

F3685

Sigma-Aldrich

Fibroblast Growth Factor-Basic, human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, carrier free, suitable for cell culture

Synonym(e):

FGB-b, FGF-2, HBGF-2, HBGH-2, Prostatropin, bFGF

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.77

product name

Fibroblast Growth Factor-Basic, FGF-Basic, from human, recombinant, expressed in E. coli, carrier free

Biologische Quelle

human

Qualitätsniveau

Rekombinant

expressed in E. coli

Assay

≥97% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

<1 ng/mL Biological Activity EC50

Mol-Gew.

16.0 kDa

Verpackung

pkg of 4X25 μg
pkg of 25 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Farbe

white to faint yellow cast

Löslichkeit

water: soluble 0.025 mg, clear, colorless to faintly yellow

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

Angaben zum Gen

human ... FGF2(2247)

Allgemeine Beschreibung

Since FGF-Basic is found in a variety of organs, acts on a wide range of cell types, and has multifunctional actions, it has acquired numerous synonyms, including heparin-binding growth factor (class II or beta), eye-derived growth factor I, cartilage-derived growth factor, and astroglial growth factor II5. Purified bovine and human FGF-basic differ by 3 amino acids in sequence3, and are biologically and immunologically cross-reactive.

Quellenangabe

1. Gospodarowicz, D., Localization of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature, 249, 123-127 (1974).
2. Gospodarowicz, D. et al., Structural characterization and biological functions of fibroblast growth factor. Endo. Rev., 8, 95-114 (1987).
3. Esch, F. et al., Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF. Proc. Natl. Acad. Sci. USA, 82, 6507-6511 (1985).
4. Neufeld, G., and Gospodarowicz, D., Basic and acidic fibroblast growth factors interact with the same cell surface receptors. J. Biol. Chem., 261, 5631-5637 (1986).
5. Lobb, R.R. et al., Purification of heparin-binding growth factors. Anal. Biochem., 154, 1-14 (1986).
6. Abraham, J.A., Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO J., 5, 2523- 2528 (1986).

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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