SRP3210
IL-33 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(e):
NF-HEV
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
mouse
Rekombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
Form
lyophilized
Wirksamkeit
≤10 ng/mL ED50
Mol-Gew.
17.5 kDa
Verpackung
pkg of 10 μg
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
<0.1 EU/μg endotoxin, tested
Farbe
white to off-white
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
mouse ... IL33(77125)
Allgemeine Beschreibung
IL-33 (interleukin 33) is an IL-1 family member, and shows high expression levels in endothelial cells and epithelium, such as keratinocytes, that are in direct contact with the environment.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
Biochem./physiol. Wirkung
IL-33 (interleukin 33) functions as an extracellular cytokine, and also translocates to the nucleus where it inhibits gene expression. It acts as a ligand for ST2/ IL-1 receptor-like 1 (growth STimulation expressed gene 2), and ST2 is expressed on cells such as CD34+ hematopoietic progenitor cells, eosinophils, basophils, T-helper 2 cell (Th2), and dendritic, NK (natural killer), endothelial and mast cells. Polymorphisms in this gene as well as its receptor are linked with atopic dermatitis, allergies and asthma. In Orientia tsutsugamushi-infected mice, IL-33 is involved in endothelial cell damage and renal injury.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
Sequenz
SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI
Physikalische Form
Lyophilized from 10 mM Sodium Phosphate, pH 8.0 + 750mM NaCl.
Rekonstituierung
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice.
Shelite TR et al
PLoS Neglected Tropical Diseases, 10(3), e0004467-e0004467 (2016)
Targeting the IL-1 family members in skin inflammation.
Jensen LE
Current Opinion in Investigational Drugs, 11(11), 1211-1220 (2010)
Ying Lei et al.
PloS one, 10(7), e0133774-e0133774 (2015-07-28)
In several clinical and experimental studies IL-33 and its receptor have been found to play important roles in the development of asthma and allergic airway inflammation. We evaluated the effects of vaccination against IL-33 in a mouse model of airway
Elizabeth A Oczypok et al.
The Journal of allergy and clinical immunology, 136(3), 747-756 (2015-05-02)
Single nucleotide polymorphisms in the human gene for the receptor for advanced glycation end-products (RAGE) are associated with an increased incidence of asthma. RAGE is highly expressed in the lung and has been reported to play a vital role in
Amy K Y Fu et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(19), E2705-E2713 (2016-04-20)
Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in
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