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SRP2077

Sigma-Aldrich

p53 (1-363) C-terminal deletion human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

Synonym(e):

FLJ92943, LFS1, P53, TRP53

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About This Item

UNSPSC-Code:
12352200
NACRES:
NA.26

Biologische Quelle

human

Rekombinant

expressed in insect cells

Assay

≥80% (SDS-PAGE)

Form

frozen liquid

Mol-Gew.

~41.8 kDa

Verpackung

pkg of 5 μg

Konzentration

850 μg/mL

Farbe

clear colorless

NCBI-Hinterlegungsnummer

NM_000546

UniProt-Hinterlegungsnummer

P04637

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... TP53(7157)

Biochem./physiol. Wirkung

Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, whereas the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function.

Physikalische Form

Clear and colorless frozen liquid solution

Angaben zur Herstellung

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
123227018

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Die Dokumentenbibliothek aufrufen

X Chen et al.
Genes & development, 10(19), 2438-2451 (1996-10-01)
It is well established that induction of the p53 tumor suppressor protein in cells can lead to either cell cycle arrest or apoptosis. To further understand features of p53 that contribute to these cell responses several p53-null Saos2 and H1299
W S el-Deiry et al.
Nature genetics, 1(1), 45-49 (1992-04-01)
Recent experiments have suggested that p53 action may be mediated through its interaction with DNA. We have now identified 18 human genomic clones that bind to p53 in vitro. Precise mapping of the binding sequences within these clones revealed a
M Hollstein et al.
Science (New York, N.Y.), 253(5015), 49-53 (1991-07-05)
Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues.

Artikel

Oncogenes and Tumor Suppressors Reprogram Metabolism

Sigma-Aldrich presents an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

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