SRP2051

HMG1, native from calf thymus

≥85% (SDS-PAGE)

• UNSPSC-Code: 12352200
• NACRES: NA.26

Eigenschaften

• Biologische Quelle: bovine (calf) thymus
• Assay: ≥85% (SDS-PAGE)
• Form: frozen liquid
• Mol-Gew.: ~24.9 kDa
• Verpackung: pkg of 10 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Konzentration: 900 μg/mL
• Methode(n): membrane array: suitable
• Farbe: colorless to clear
• NCBI-Hinterlegungsnummer: X12796
• UniProt-Hinterlegungsnummer: P10103
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: bovine ... HMG1() , HMGB1(282691)

Beschreibung

Biochem./physiol. Wirkung

High mobility group 1 (HMG1) is a 26 kDa highly conserved non-sequence-specific DNA-binding nuclear protein. Mammalian HMG1 has two homologous DNA-binding domains HMG boxes, A and B (each of 80–90 amino-acid residues), linked by a short basic region to an acidic C-terminal domain containing 30 consecutive Asp and Glu residues. HMG1 has been implicated in a number of fundamental biological processes including transcription, replication and recombination, in which it plays a role in manipulating DNA structure by bending, looping, compaction or unwinding, or by directly contacting with distinct cellular proteins. HMG-1 can act as a repressor, by interacting with TBP to block pre-initiation complex formation or as an activator, by facilitating the binding of various transcription factors to their cognate DNA sequences. Most recently, it was discovered that HMG-1 is a late mediator of delayed endotoxin lethality by activating downstream cytokine release.

Physikalische Form

Clear and colorless frozen liquid solution

Angaben zur Herstellung

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable