SRP0570

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

• Synonym(e): 5′- nucleotidase, Ecto-5′-nucleotidase
• UNSPSC-Code: 12352202
• NACRES: NA.26

Eigenschaften

• Rekombinant: expressed in HEK 293 cells
• Form: frozen liquid
• Mol-Gew.: 58.6 kDa
• UniProt-Hinterlegungsnummer: P21589
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... NT5E(4907)

Beschreibung

Allgemeine Beschreibung

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

Anwendung

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

Biochem./physiol. Wirkung

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

Physikalische Form

Aqueous solution

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable