SML3742

GK13S

≥98% (HPLC)

• Synonym(e): (S)-1-Cyano-N-(1-(4-(pent-4-yn-1ylcarbamoyl)phenyl)-1H-imidazol-4-yl)pyrrolidine-3-carboxamide
• Empirische Formel (Hill-System): C₂₁H₂₂N₆O₂
• Molekulargewicht: 390.44
• MDL-Nummer: MFCD35067861
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

Cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1; chemogenomic probe suitable for the cellular study of UCHL1.


GK13S is a cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1. GK13S, but not GK16S, led to the reduction of monoubiquitin levels in the human glioblastoma cell line U-87 MG. GK13S together with GK16S comprises a set of chemogenomic probes for UCHL1, which is suitable for investigation of cellular functions of UCHL. GK13S also binds to PARK7, C21orf33, ISOC1 andNIT2.