SML3338

NF-56-EJ40

≥98% (HPLC)

• Synonym(e): 2-(2-(4′-((4-Methylpiperazin-1-yl)methyl)biphenyl-3-ylcarboxamido)phenyl)acetic acid, 2-(2-(4′-((4-methylpiperazin-1-yl)methyl)-[1,1′-biphenyl]-3-carboxamido)phenyl)acetic acid, 2-[[[4′-[(4-Methyl-1-piperazinyl)methyl][1,1′-biphenyl]-3-yl]carbonyl]amino]-benzeneacetic acid
• Empirische Formel (Hill-System): C₂₇H₂₉N₃O₃
• CAS-Nummer: 2380230-73-7
• Molekulargewicht: 443.54
• MDL-Nummer: MFCD32263439
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: 2-8°C

Beschreibung

Biochem./physiol. Wirkung

NF-56-EJ40 is a high-affinity, potent and human species-selective succinate receptor SUCNR1 (GPR91) antagonist (human GPR91 Ki/KD = 17.4/33 nM; GTPγS assay IC50 = 25 nM/human, >100 μM/rat). Extracellular succinate is reported to hyperpolarize M2 macrophages through GPR91-mediated Gq signaling, blockable by NF-56-EJ40 (1 μM) or Gq inhibitor YM-254890 (1 μM).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable