SML3118

Obatoclax mesylate

≥98% (HPLC)

• Synonym(e): 2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole, methanesulfonate salt, GX15-070 mesylate
• Empirische Formel (Hill-System): C₂₀H₁₉N₃O · CH₄O₃S
• CAS-Nummer: 803712-79-0
• Molekulargewicht: 413.49
• MDL-Nummer: MFCD18074508
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: dark green to black
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC

Beschreibung

Biochem./physiol. Wirkung

Obatoclax (GX15–070) is a BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins, including A1/Bfl-1, Bcl-2, Bcl-B, Bcl-w, Bcl-XL, and MCL-1. Obatoclax induces cancer cell apoptosis in cultures (0.05-2 μM) and in vivo (1.25-10 mg/kg via im. ip. or iv. in mice) by overcoming Bcl-2 members-mediated resistance to BAX- or BAK-dependent apoptosis.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H315
• P-Sätze: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P332 + P313
• Gefahreneinstufungen: Acute Tox. 3 Oral - Skin Irrit. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable