SML2774

KDOAM25 hydrochloride hydrate

≥98% (HPLC)

• Synonym(e): 2-[[[2-[2-(Dimethylamino)ethyl-ethyl-amino]-2-oxidanylidene-ethyl]amino]methyl]pyridine-4-carboxamide hydrochloride hydrate, 2-[[[2-[2-(Dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridine-4-carboxamide hydrochloride hydrate, KDOAM-25 hydrochloride hydrate
• Empirische Formel (Hill-System): C₁₅H₂₅N₅O₂ · xHCl · yH₂O
• Molekulargewicht: 307.39 (anhydrous free base basis)
• MDL-Nummer: MFCD30146416
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: N(CCN(CC)C(=O)CNCc1nccc(c1)C(=O)N)(C)C
• InChIKey: PNFMVADNCOGWME-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC₅₀ values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.

Selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable