SML2556

Pt-ttpy

>97% (NMR)

• Synonym(e): (SP-4-2)-Chloro[4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine-κN1,κN1′,κN1′′]-Platinum(1+) chloride, Tolylterpyridin-platin
• Empirische Formel (Hill-System): C₂₂H₁₇Cl₂N₃Pt
• CAS-Nummer: 727721-37-1
• Molekulargewicht: 589.37
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: >97% (NMR)
• Form: powder
• Farbe: faint yellow to dark orange
• Löslichkeit: DMSO: 0.2 mg/mL (warmed)
• Lagertemp.: 2-8°C
• SMILES String: CC1=CC=C(C2=CC(C3=[N+]4C=CC=C3)=[N+]5C(C6=CC=CC=[N+]6[Pt-2]54Cl)=C2)C=C1.[Cl-]

Beschreibung

Biochem./physiol. Wirkung

Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable