SML1974

CBLC000 trifluoroacetate

≥95% (HPLC)

• Synonym(e): 9H-Carbazole-9-ethanamine, N,N-diethyl-3,6-dinitro- trifluoroacetate, Curaxin CBLC000 trifluoroacetate, N,N-Diethyl-3,6-dinitro-9H-carbazole-9-ethanamine trifluoroacetate
• Empirische Formel (Hill-System): C₁₈H₂₀N₄O₄ · C₂HF₃O₂
• CAS-Nummer: 324780-02-1
• Molekulargewicht: 470.40
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CCN(CC)CCN1C2=C(C=C([N+]([O-])=O)C=C2)C3=C1C=CC([N+]([O-])=O)=C3.FC(F)(C(O)=O)F
• InChI: 1S/C18H20N4O4.C2HF3O2/c1-3-19(4-2)9-10-20-17-7-5-13(21(23)24)11-15(17)16-12-14(22(25)26)6-8-18(16)20;3-2(4,5)1(6)7/h5-8,11-12H,3-4,9-10H2,1-2H3;(H,6,7)
• InChIKey: VFGJIBCWHYFSHE-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

CBLC000 is a potent inhibitor of FACT (facilitates chromatin transcription) complex that activates p53 and suppresses NF-kB without genotoxicity. CBLC000 induces chromatin trapping of FACT both in vitro and in vivo. CBLC000 exhibits brad anticancer activity. CBLC000 analog clinical candidate CBL0137 decreases self-renewal of GBM stem cells (GSC).

Potent inhibitor of FACT complex that activates p53 and suppresses NF-kB without genotoxicity

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H413
• P-Sätze: P273 - P301 + P312 + P330 - P302 + P352
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 4 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable