Q2876

Chinakrin-Senf -dihydrochlorid

≥85% (HPLC)

• Synonym(e): 2-Methoxy-6-chlor-9-(4-bis-[β-chlorethyl]-amino-1-methylbutylamino)-acridin -dihydrochlorid, 9-[4-(Bis-(2-chlorethyl)-amino)-1-methylbutylamino]-6-chlor-2-methoxyacridin -dihydrochlorid
• Empirische Formel (Hill-System): C₂₃H₂₈Cl₃N₃O · 2HCl
• CAS-Nummer: 4213-45-0
• Molekulargewicht: 541.77
• Beilstein: 3819822
• EG-Nummer: 224-140-9
• MDL-Nummer: MFCD00043254
• UNSPSC-Code: 12352101
• PubChem Substanz-ID: 24899329
• NACRES: NA.32

Eigenschaften

• Assay: ≥85% (HPLC)
• Lagertemp.: −20°C
• SMILES String: Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1
• InChI: 1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H
• InChIKey: JETDZFFCRPFPDH-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Quinacrine mustard dihydrochloride is a fluorescent acridine dye, also abbreviated as QM. In an aqueous solution, the chloroethyl groups rapidly lose chloride ions yielding aziridinium cations. These readily react with the carboxyl, thiol, and heterocyclic ring nitrogen groups of proteins and nucleic acids, or with other nucleophiles.

Anwendung

Quinacrine mustard dihydrochloride is used to stain metaphase chromosomes. Recent applications include the Q-banding of maize and karyotyping of fish. The dye is also used as a vital stain for trypanosomes.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301 + H331,H317,H334,H361
• P-Sätze: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges