SML1873

(2R,6R)-Hydroxynorketamine hydrochloride

≥98% (HPLC)

• Synonym(e): (2R,6R)-HNK hydrochloride; (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxy-cyclohexanone hydrochloride
• Empirische Formel (Hill-System): C₁₂H₁₄ClNO₂ · HCl
• CAS-Nummer: 1430202-69-9
• Molekulargewicht: 276.16
• MDL-Nummer: MFCD30182371
• UNSPSC-Code: 12352116
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D -95 to -115°, c = 1 in H₂O
• Arzneimittelkontrolle: regulated under CDSA - not available from Sigma-Aldrich Canada
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 25 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C1[C@@](C2=CC=CC=C2Cl)(N)CCC[C@H]1O.Cl

Beschreibung

Biochem./physiol. Wirkung

(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319
• P-Sätze: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable