SML1639

BRD3308

≥98% (HPLC)

• Synonym(e): 4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide
• Empirische Formel (Hill-System): C₁₅H₁₄FN₃O₂
• CAS-Nummer: 1550053-02-5
• Molekulargewicht: 287.29
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825980
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CC(NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1)=O
• InChI: 1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21)
• InChIKey: RRJDFENBXIEAPD-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC₅₀ value of 65 nM for HDAC3 vs. IC₅₀ values of 1.08 μM and 1.15 μM for HDAC1 and HDAC2, respectively. BRD3308 protected pancreatic β cells, suppressing inflammatory cytokine-induced apoptosis and increasing insulin release without the toxicity associated with HDAC1 and HDAC2 inhibitors. In a rat model of type 2 diabetes, BRD3308 reduced hyperglycemia and increased insulin secretion without affecting weight gain. In another study, BRD3308 was found to activate HIV-1 transcription, disrupting HIV-1 latency.

BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3).

BRD3308 promotes outgrowth of HIV-1 (human immunodeficiency virus 1) from inactive infected patient cells. It helps to increase β-cell proliferation.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable