SML1538

NMDI14

≥97% (HPLC)

• Synonym(e): 4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
• Empirische Formel (Hill-System): C₂₁H₂₅N₃O₄S
• CAS-Nummer: 307519-88-6
• Molekulargewicht: 415.51
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 0.2 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C

Beschreibung

Anwendung

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:

• to study its effects on differentiating cardiomyocytes
• to study its effects on zebrafish pdzk1 gene-knockout embryos
• to analyze its effects on the apoptosis of colorectal cancer cells

Biochem./physiol. Wirkung

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable