SML1509

MK6-83

≥98% (HPLC)

• Synonym(e): 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
• Empirische Formel (Hill-System): C₁₆H₂₀N₂O₂S₂
• CAS-Nummer: 1062271-24-2
• Molekulargewicht: 336.47
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to brown
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• InChI: 1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
• InChIKey: IRGYSXZCDAWOOC-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.

MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable