SML1451

MI192 hydrochloride

≥98% (HPLC)

• Synonym(e): N-(2-Aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide hydrochloride, MI-192 hydrochloride
• Empirische Formel (Hill-System): C₂₄H₂₁N₃O₂ · xHCl
• CAS-Nummer: 1415340-63-4
• Molekulargewicht: 383.44 (free base basis)
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825890
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to light brown
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: C=C(CN1CC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2)C4=CC=CC=C4C1=O
• InChI: 1S/C24H21N3O2/c1-16-14-27(24(29)20-7-3-2-6-19(16)20)15-17-10-12-18(13-11-17)23(28)26-22-9-5-4-8-21(22)25/h2-13H,1,14-15,25H2,(H,26,28)
• InChIKey: GTLTXEIKQVWSRF-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

MI192 is a potent and selective histone deacetylase 3 (HDAc 3) inhibitor that inhibits IL-6 production in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) but not healthy PBMCs.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable