SML0907

Apoptolidin A Ready Made Solution

1 mg/mL in DMSO

• Synonym(e): Apoptolidin, FU 40A
• Empirische Formel (Hill-System): C₅₈H₉₆O₂₁
• CAS-Nummer: 194874-06-1
• Molekulargewicht: 1129.37
• EG-Nummer: 200-664-3
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825615
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: Amycolatopsis sp.
• Qualitätsniveau: 200
• Form: DMSO solution
• Konzentration: 1 mg/mL in DMSO
• Wirkungsspektrum von Antibiotika: fungi
• Wirkungsweise: enzyme | inhibits
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O
• InChI: 1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
• InChIKey: WILMROCKORZEMQ-XIQAQMKHSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: macrolide

Biochem./physiol. Wirkung

Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F₀F₁-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E₁A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): 188.6 °F
• Flammpunkt (°C): 87 °C