SML0847

Benzatropin -methansulfonat (Salz)

≥98% (HPLC)

• Synonym(e): Benzatropine mesylate, Benzotropine mesylate, Benztropine methanesulfonate
• Empirische Formel (Hill-System): C₂₁H₂₅NO · CH₃SO₃H
• CAS-Nummer: 132-17-2
• Molekulargewicht: 403.53
• EG-Nummer: 205-048-8
• MDL-Nummer: MFCD00074784
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825609
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4
• InChI: 1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;
• InChIKey: CPFJLLXFNPCTDW-BWSPSPBFSA-N
• Angaben zum Gen: human ... CHRM1(1128)

Beschreibung

Allgemeine Beschreibung

Benztropine mesylate is an anti-histamine and dopamine re-uptake inhibitor.

Anwendung

Benztropine mesylate has been used to study its target identification and mode of action against ebolavirus infection. It has also been used in pharmacological animal studies to evaluate its effect on SLC6A19 (solute carrier family 6 member 19; B0AT1).

Biochem./physiol. Wirkung

Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC₅₀ = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.

Benztropine mesylate serves as an inhibitor of breast cancer stem cells (BCSCs) in vitro and in vivo. It can help in improving the efficacy of chemotherapy in vitro. It is considered as an anti-cancer stem cell (CSC) drug, which can modify tumorigenic properties.

Leistungsmerkmale und Vorteile

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This compound is featured on the Acetylcholine Receptors (Muscarinic) and Biogenic Amine Transporters pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H302,H311 + H331
• P-Sätze: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable