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SML0810

Sigma-Aldrich

MHY1485

≥95% (HPLC)

Synonym(e):

4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

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About This Item

Empirische Formel (Hill-System):
C17H21N7O4
CAS-Nummer:
Molekulargewicht:
387.39
UNSPSC-Code:
12352200
NACRES:
NA.77

Assay

≥95% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 2 mg/mL, clear (warmed)

Lagertemp.

2-8°C

InChI

1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)

InChIKey

MSSXBKQZZINCRI-UHFFFAOYSA-N

Anwendung

MHY1485 has been used:
  • to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
  • to inhibit autophagy
  • as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Biochem./physiol. Wirkung

MHY1485 binds to the mammalian target of rapamycin (mTOR) and stimulates its action. MHY1485 has the ability to penetrate the cell. It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts.
MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling
Yang Bo, et al.
Oncotarget, 8(8), 12775-12775 (2017)
O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5
Wu N, et al.
Journal of Cellular and Molecular Medicine, 23(2), 1354-1362 (2019)
ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic
Gan W, et al.
BMC Cell Biology, 18(1), 22-22 (2017)
Duc-Vinh Pham et al.
Journal of experimental & clinical cancer research : CR, 41(1), 9-9 (2022-01-07)
Adiponectin, the most abundant adipokine derived from adipose tissue, exhibits a potent suppressive effect on the growth of breast cancer cells; however, the underlying molecular mechanisms for this effect are not completely understood. Fatty acid metabolic reprogramming has recently been
MHY1485 activates mTOR and protects osteoblasts from dexamethasone
Zhao S, et al.
Biochemical and biophysical research communications, 481(3-4), 212-218 (2016)

Protokolle

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