SML0560

BRACO19 hydrochloride

≥96% (HPLC), powder, telomerase inhibitor

• Synonym(e): N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride
• Empirische Formel (Hill-System): C₃₅H₄₃N₇O₂ · xHCl
• CAS-Nummer: 1177798-88-7
• Molekulargewicht: 593.76 (free base basis)
• MDL-Nummer: MFCD23380200
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825553
• NACRES: NA.77

Eigenschaften

• product name: BRACO19 hydrochloride, ≥96% (HPLC)
• Assay: ≥96% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: yellow to brown
• Löslichkeit: H₂O: 5 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1
• InChI: 1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H
• InChIKey: MJAPNWJRLLDPAB-UHFFFAOYSA-N

Beschreibung

Anwendung

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).

Biochem./physiol. Wirkung

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment. BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable