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Merck

SML0307

Sigma-Aldrich

Pleconaril

≥98% (HPLC)

Synonym(e):

3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole, VP 63843, Win 63843

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About This Item

Empirische Formel (Hill-System):
C18H18F3N3O3
CAS-Nummer:
Molekulargewicht:
381.35
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: ≥10 mg/mL (warmed)

Lagertemp.

room temp

SMILES String

Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1

InChI

1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3

InChIKey

KQOXLKOJHVFTRN-UHFFFAOYSA-N

Allgemeine Beschreibung

Pleconaril is a drug, that has antiviral activity.

Anwendung

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

Biochem./physiol. Wirkung

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. Also, pleconaril delays the onset of diabetes in experimental animals infected with Ljungan virus (LV).

Piktogramme

Skull and crossbones

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Acute Tox. 3 Oral - Aquatic Chronic 4

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Viral infections
Textbook of Clinical Neurology (Third Edition), 919-942 (2007)
A novel series of highly potent small molecule inhibitors of rhinovirus replication
Kim J, et al.
Journal of Medicinal Chemistry, 60(13), 5472-5492 (2017)
Microscopic determination of drug solubility in plasma and calculation of injection rates with a plasma circulatory model to prevent precipitation on intravenous injection.
G A Portmann et al.
Journal of pharmaceutical and biomedical analysis, 13(9), 1189-1193 (1995-08-01)
Chronic meningoencephalitis caused by Echo virus 6 in a patient with common variable immunodeficiency
Radanovic I, et al.
Wiener Klinische Wochenschrift, 130(1-2), 70-72 (2018)
Chunlong Ma et al.
ACS infectious diseases, 5(11), 1952-1962 (2019-09-19)
Enterovirus D68 (EV-D68) is a respiratory viral pathogen that primarily infects children under the age of 8. Although EV-D68 infection typically leads to moderate to severe respiratory illnesses, recent years have seen increasing cases of EV-D68 triggered neurological complications such

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